There is one unique ZIP code in Santa Fe, Missouri and it is 65282. Area code: 573.
1
ZIP codes
11.11
sq mi land
0.77
sq mi water
573
area code
Santa Fe, MO ZIP code map
About Santa Fe, MO
Santa Fe is a quaint city located in Monroe County, Missouri. With its charming landscape, it paints a picturesque view of rural life in the Midwest. Residents enjoy a close-knit community atmosphere surrounded by natural beauty.
Location & geography
Santa Fe is located in the northern part of Missouri, just southwest of the town of Monroe City. Nearby cities include Paris, which is about 12 miles to the west, and the larger city of Moberly, approximately 15 miles to the northwest. The city spans a total land area of 11.11 square miles, with 0.77 square miles of that covered by water, offering a mix of both terrestrial and aquatic environments.
Community & economy
The character of Santa Fe reflects a classic Midwestern small town, where community members take pride in their local heritage. The local economy is supported by agriculture and small businesses, which play a significant role in daily life. Residents often gather for local events and fairs that celebrate the culture of this rural area.
Transportation
Santa Fe is accessible via Highway 24, which connects it to larger routes and neighboring towns. The nearest major airport is the Columbia Regional Airport, which is roughly 40 miles to the southwest, providing connectivity for longer-distance travel. Local transit options are limited, making personal vehicles the primary mode of transportation.
History
Santa Fe was founded in the mid-19th century and has historically relied on agriculture as a key industry for its economic development. The city has experienced fluctuations in growth related to economic changes, but it remains a charming snapshot of rural Missouri history. Notably, Santa Fe has maintained its identity through various community events and local traditions that hark back to its founding.
Did you know?
A surprising fact about Santa Fe is that despite its small size, it has a strong sense of community spirit, with local events that draw residents together from surrounding areas. Additionally, being situated near water bodies adds a unique charm that attracts visitors interested in nature and outdoor activities.
Source: U.S. Census Bureau, American Community Survey 2025 estimates.
Frequently asked questions
What is the ZIP code for Santa Fe, MO?
Santa Fe, MO has one ZIP code: 65282.
What is the main ZIP code for Santa Fe, MO?
The primary ZIP code for Santa Fe, MO is 65282. The city uses area code 573 for phone service.
What county is Santa Fe, MO in?
Santa Fe is located in Monroe County, Missouri.
How many ZIP codes are in Santa Fe, MO?
Santa Fe, MO has 1 ZIP code.
What is the ZIP code for downtown Santa Fe in Monroe County?
Downtown Santa Fe, Missouri is located in ZIP code 65282, which serves as the primary postal code for the city's central business district and historic areas.
If I'm mailing something to a business in Santa Fe, Missouri, which ZIP code should I use?
All mailing addresses in Santa Fe, Missouri use the ZIP code 65282, as it is the sole ZIP code designated for this Monroe County community.
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